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Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
(BioMed Central, 2020)
Background: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric ...
Identification of new inhibitors of Mdm2-p53 interaction via pharmacophore and structure-based virtual screening
(Dove Medical Press Ltd., 2018)
Background: The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the ...
Anti-dengue, cytotoxicity, antifungal, and in silico study of the newly synthesized 3-O-Phospo-α-D-glucopyranuronic acid compound
(Hindawi., 2018)
The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance.The chemical structure of compound 7 (methyl 3-O-phospo-D-glucopyranuronic acid was elucidated by physical and ...
Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity
(John Wiley and Sons Ltd., 2018)
The presence of false positives in enzyme inhibition assays is a common problem in early drug discovery, especially for compounds that form colloid aggregates in solution. The molecular basis of these aggregates could not ...
Controlled release of pyrimidine compound using polymeric coated ZIF-8 metal-organic framework as glucagon-like peptide-1 receptor agonist carrier
(MDPI AG., 2020)
This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment ...
Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
(MDPI AG., 2020)
The endoplasmic reticulum (ER) is an important organelle involved in protein quality
control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress,
followed by an adaptive response via the ...
Anti-inflammatory, antibacterial, toxicological profile, and in silico studies of dimeric naphthoquinones from diospyros lotus
(International Academic Press, 2020)
Many researchers have studied socioeconomic, health, and security variables in developed countries; however, very few studies used multivariate analysis in developing countries. The current study contributes to the scarce ...
Non Pharmaceutical Interventions for Optimal Control of COVID-19
(Elsevier, 2020)
Background and Objective: The outbreak of the current pandemic begun from the first individual of a 55-year old from Hubei province in China, the disease instigated by the new coronavirus spreading across the world. ...
iOntoBioethics: A Framework for the Agile Development of Bioethics Ontologies in Pandemics, Applied to COVID-19
(Frontiers Media S.A., 2021)
Background: Few ontological attempts have been reported for conceptualizing the bioethics domain. In addition to limited scope representativeness and lack of robust methodological approaches in driving research design and ...
COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies
(MDPI, 2020)
Coronavirus disease 2019 (COVID-19), which reported in an outbreak in 2019 in Wuhan, Hubei province, China, is caused by the SARS-CoV-2 virus. The virus belongs to the beta-coronavirus class, along with the Middle East ...