Browsing Publications by Title
Now showing items 1-20 of 269
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Activation of the GLP-1 receptor by chloropyrimidine derivatives
(Elsevier B.V., 2021)The anti-diabetic activities of a series of chloropyrimidine derviatives 2a-k and 4a-k were investigated after they were designed, synthesized, and docked against the GLP-1 receptor target. In comparison to exenatide, which ... -
Aducanumab Therapy to Treat Alzheimer's Disease: A Narrative Review
(Hindawi Limited, 2022)Background. Aducanumab, a new monoclonal antibody that targets β-amyloid aggregates, has been granted conditional approval by the U.S. FDA for treatment of mild Alzheimer's disease (AD). The approval of this drug without ... -
Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents
(Dove Medical Press Ltd, 2022)The current pandemic caused by the COVID-19 disease has reached everywhere in the world and has affected every aspect of our lives. As of the current data, the World Health Organization (WHO) has reported more than 300 ... -
Amphiphilic Alkylated Pectin Hydrogels for Enhanced Topical Delivery of Fusidic Acid: Formulation and In Vitro Investigation
(MDPI, 2022)Hydrogels constructed of amphiphilically modified polysaccharides have attracted a lot of interest because of their potential to augment drug diffusion over the skin. This research describes the synthesis of amphiphilic ... -
Amphiphilic Alkylated Pectin Hydrogels for Enhanced Topical Delivery of Fusidic Acid: Formulation and In Vitro Investigation
(MDPI, 2022)Hydrogels constructed of amphiphilically modified polysaccharides have attracted a lot of interest because of their potential to augment drug diffusion over the skin. This research describes the synthesis of amphiphilic ... -
Anti-convulsant effects of bongardia chrysogonum L. Tuber in the pentylenetetrazole-induced seizure model
(Asian Network for Scientific Information, 2017)Background and Objective: The dried tuber of Bongardia chrysogonum (L.) is a popular folk remedy for its use in the treatment of epilepsy in traditional medicine. The study aimed to evaluate the anti-oxidant and anti-convulsant ... -
Anti-dengue, cytotoxicity, antifungal, and in silico study of the newly synthesized 3-O-Phospo-α-D-glucopyranuronic acid compound
(Hindawi., 2018)The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance.The chemical structure of compound 7 (methyl 3-O-phospo-D-glucopyranuronic acid was elucidated by physical and ... -
Anti-inflammatory agents of the carbamoylmethyl ester class: Synthesis, characterization, and pharmacological evaluation
(Dove Medical Press Ltd., 2013)In this study, target compounds 5-12 were synthesized via acid amine coupling of ibuprofen and naproxen with methyl ester derivatives of amino acids, namely, l-proline, sarcosine, l-tyrosine, and l-glutamic acid. When ... -
Anti-inflammatory and anti-oxidant properties of Ipomoea nil (Linn.) Roth significantly alleviates cigarette smoke (CS)-induced acute lung injury via possibly inhibiting the NF-κB pathway
(Elsevier Masson s.r.l., 2022)Acute respiratory distress syndrome (ARDS), a serious manifestation of acute lung injury (ALI), is a debilitating inflammatory lung disease that is caused by multiple risk factors. One of the primary causes that can lead ... -
Anti-inflammatory, antibacterial, toxicological profile, and in silico studies of dimeric naphthoquinones from diospyros lotus
(International Academic Press, 2020)Many researchers have studied socioeconomic, health, and security variables in developed countries; however, very few studies used multivariate analysis in developing countries. The current study contributes to the scarce ... -
Antibiotic Prescribing Patterns for Outpatient Pediatrics at a Private Hospital in Abu Dhabi: A Clinical Audit Study
(MDPI, 2022)Background: Antibiotics are commonly used in pediatrics. The aim and objectives were to evaluate the antibiotic prescribing patterns of pediatric outpatients at a private hospital in Abu Dhabi, UAE. Methods: A retrospective ... -
Antibiotic prescribing practices and errors among hospitalized pediatric patients suffering from acute respiratory tract infections: A multicenter, cross-sectional study in pakistan
(MDPI AG., 2019)Background and objective: The noncompliance of treatment guidelines by healthcare professionals, along with physiological variations, makes the pediatric population more prone to antibiotic prescribing errors. The present ... -
Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives
(MDPI AG., 2011)A new series of 1,3-thiazole and benzo[d] thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as ... -
Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)Suaeda fruticosa Forssk. Ex J.F.Gmel is traditionally used for inflammatory and digestive disorders, as a carminative, and for diarrhea. This plant is widely distributed in Asia, Africa, and the Mediterranean region. Aqueous ... -
Application of the American College of Cardiology (ACC/AHA) 2017 Guideline for the Management of Hypertension in Adults and Comparison with the 2014 Eighth Joint National Committee Guideline
(Saudi Heart Association, 2021)Objectives: This study aims to compare the 2017-ACC/AHA hypertension guideline with 2014-JNC-8 guideline in re-gard to the number of patients who are eligible for treatment and to determine the physicians’ adherence and ... -
Applying medicines reconciliation indicators in two UK hospitals: a feasibility study
(Oxford University Press, 2021)ObjectivesThe aim of this study was to apply the Medicines reconciliation (MR) indicators and to assess their feasibility for use with patients on admission. MethodsThis is a mixed-methods study conducted in two large ... -
Appropriateness of antibiotic prescription among hospitalized patients with urinary tract infection in Jordan
(Open Science Publishers LLP Inc., 2023)Lack of adherence to recent antibiotic prescription guidelines leads to antibiotic resistance which causes treatment failure and the development of disease complications in patients with urinary tract infection (UTI). The ... -
Are we ready yet for digital transformation? Virtual versus on-campus OSCE as assessment tools in pharmacy education. A randomized controlled head-to-head comparative assessment
(Elsevier B.V., 2023)Background: The global COVID-19 pandemic has influenced pharmacy education including learning, assessment, and exams. In the UAE, pharmacy instructors have adapted several innovative teaching methods to strive for quality ... -
Artemisia species and artemisinin derivatives as antiviral agents against COVID-19. current knowledge: Chemistry, pharmacology and clinical evidence
(Romanian Society for Pharmaceutical Sciences, 2022)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been the reason behind the third zoonotic outbreak from the Coronaviridae family during the 21st century. COVID-19 was declared a pandemic by the WHO on 11 ... -
Assessing adherence to medications: Is there a differencbetween a subjective method and an objective method, between using them concurrently?
(Grupo de Investigacion en Atencion Farmaceutica, 2022)Background: Patients’ adherence to medication can be assessed by several subjective or objective methods. The Global Initiative for Asthma (GINA) harecommended the use of both measures simultaneously. Objective: To assess ...