Browsing Publications by Author "Mahmood, Arshad"
Now showing items 1-14 of 14
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Biofunctional Hyaluronic Acid/κ-Carrageenan InjectableHydrogels for Improved Drug Delivery and Wound Healing
Ijaz, Uzma; Sohail, Muhammad; Minhas, Muhammad Usman; Khan, Shahzeb; Hussain, Zahid; Kazi, Mohsin; Shah, Syed Ahmed; Mahmood, Arshad; Maniruzzaman, Mohammed (MDPI, 2022)The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers ... -
Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery—In Vitro and In Vivo Evaluation
Sarfraz, Muhammad; Tulain, Ume Ruqia; Erum, Alia; Malik, Nadia Shamshad; Mahmood, Arshad; Sumaira, S.; Aslam, Sidra; Sandhu, Mansur Abdullah; Tayyab, Muhammad (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The primary objective of this study was to assess the potential utility of quince seed mucilage as an excipient within a graft copolymer for the development of an oral-controlled drug delivery system. The Cydonia ... -
Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil
Akhtar, Ammara; Waqas, Muhammad Khurram; Mahmood, Arshad; Tanvir, Saira; Hussain, Talib; Kazi, Mohsin; Ijaz, Muhammad; Asim, Mulazim Hussain (Multidisciplinary Digital Publishing Institute (MDPI), 2023-12)Purpose: The aim of this research was to prepare adhesive nanoparticles for the topical application of Minoxidil (MXD). Methods: Thiolated β-CDs were prepared via conjugation of cysteamine with oxidized CDs. MXD was ... -
Enhanced Intestinal Permeability of Cefixime by Self-Emulsifying Drug Delivery System: In-Vitro and Ex-Vivo Characterization
Mahmood, Arshad; Khan, Laraib; Ijaz, Muhammad; Nazir, Imran; Naseem, Mahrukh; Tahir, Muhammad Azam; Aamir, Muhammad Naeem; Rehman, Masood Ur; Asim, Mulazim Hussain (NLM (Medline), 2023)BACKGROUND: Cefixime (CFX) belongs to a group of third-generation cephalosporin antibiotics with low water solubility and low intestinal permeability, which ultimately leads to significantly low bioavailability. AIM: This ... -
Enhanced Oral Bioavailability of Epalrestat SBE7-β-CD Complex Loaded Chitosan Nanoparticles: Preparation, Characterization and in-vivo Pharmacokinetic Evaluation
Alvi, Zunaira; Akhtar, Muhammad; Mahmood, Arshad; Ur-Rahman, Nisar; Nazir, Imran; Sadaquat, Hadia; Ijaz, Muhammad; Syed, Shahzada Khurram; Waqas, Muhammad Khurram; Wang, Yi (NLM (Medline), 2021)Background: Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined. Purpose: Current research aimed to fabricate inclusion complexation of EPL ... -
Exploring the gelling properties of Plantago ovata-based Arabinoxylan: Fabrication and optimization of a topical emulgel using response surface methodology
Mahmood, Arshad; Erum, Alia; Tulain, Ume Ruqia; Malik, Nadia Shamshad; Saleem, Aneeqa; Alqahtani, Mohammed S.; Malik, Muhammad Zubair; Siddiqui, Mahwish; Safdar, Asif; Malik, Abdul (NLM (Medline), 2023)Prime objective of the current research was to develop a stable nimesulide emulgel with the help of arabinoxylan, a natural gelling agent extracted from Plantago ovata. The response surface methodology was used by a Design ... -
Formulation and Evaluation of Linum usitatissimum Mucilage-Based Nanoparticles for Effective Delivery of Ezetimibe
Tulain, Ume Ruqia; Mahmood, Arshad; Aslam, Sidra; Erum, Alia; Malik, Nadia Shamshad; Rashid, Ayesha; Kausar, Rizwana; Alqahtani, Mohammed S. (Dove Medical Press Ltd., 2021)Introduction: The aim of current study was to prepare Linum usitatissimum mucilage (LUM) based nanoparticles, capable of encapsulating hydrophobic drug ezetimibe as nanocarriers. Methods: Solvent evaporation and nanoprecipitation ... -
Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies
Ghumman, Shazia Akram; Mahmood, Arshad; Noreen, Sobia; Rana, Mavra; Hameed, Huma; Ijaz, Bushra; Hasan, Sara; Aslam, Afeefa; Fayyaz ur Rehman, Muhammad (Elsevier B.V., 2022)Quince seed mucilage was used in a combination of sodium alginate to develop sustained-release microspheres of cefixime. Physical characterizations such as FTIR, TGA, DSC, and SEM were performed on the prepared microspheres. ... -
Highly Responsive Chitosan-Co-Poly (MAA) Nanomatrices through Cross-Linking Polymerization for Solubility Improvement
Saleem, Anam; Akhtar, Naveed; Minhas, Muhammad Usman; Mahmood, Arshad; Ullah Khan, Kifayat; Abdullah, Orva (MDPI, 2022)In this study, we report the highly responsive chitosan-based chemically cross-linked nanomatrices, a nano-version of hydrogels developed through modified polymerization reaction for solubility improvement of poorly soluble ... -
Mimosa pudica mucilage nanoparticles of losartan potassium: Characterization and pharmacodynamics evaluation
Ghumman, Shazia Akram; Mahmood, Arshad; Noreen, Sobia; Hameed, Huma; Kausar, Rizwana; Rana, Maria; Aslam, Asma (Elsevier B.V., 2023)The current research was to develop nanoparticles based on Mimosa pudica mucilage (MPM) that could encapsulate losartan potassium (LP). Nanoparticles (NPs) produced through ionic-gelation method; the polymerization of the ... -
Papain-Decorated Mucopenetrating SEDDS: A Tentative Approach to Combat Absorption Issues of Acyclovir via the Oral Route
Mahmood, Arshad; Haneef, Rabbia; Al Meslamani, Ahmad Z.; Bostanudin, Mohammad F.; Sohail, Muhammad; Sarfraz, Muhammad; Arafat, Mosab (MDPI, 2022)The aim of the current study was to enhance the oral bioavailability of Acyclovir (ACV) based on the papain-functionalized self-emulsifying drug delivery systems (SEDDS). The optimum control SEDDS formulation comprised of ... -
Preliminary Investigation of Linum usitatissimum Mucilage-Based Hydrogel as Possible Substitute to Synthetic Polymer-Based Hydrogels for Sustained Release Oral Drug Delivery
Mahmood, Arshad; Erum, Alia; Mumtaz, Sophia; Tulain, Ume Ruqia; Malik, Nadia Shamshad; Alqahtani, Mohammed S. (MDPI, 2022)The aim of this study was to investigate the potential of Linum usitatissimum mucilage, a natural polymer, in developing a sustained release hydrogel for orally delivered drugs that require fre-quent dosing. For this ... -
Synthesis and Characterization of Carboxymethyl Chitosan Nanosponges with Cyclodextrin Blends for Drug Solubility Improvement
Rizvi, Syeda Sadia Batool; Akhtar, Naveed; Minhas, Muhammad Usman; Mahmood, Arshad; Khan, Kifayat Ullah (MDPI, 2022)This study aimed to enhance the solubility and release characteristics of docetaxel by synthesizing highly porous and stimuli responsive nanosponges, a nano-version of hydrogels with the additional qualities of both hydrogels ... -
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation
Malik, Nadia Shamshad; Ahmad, Mahmood; Alqahtani, Mohammed S.; Mahmood, Arshad; Barkat, Kashif; Khan, Muhammad Tariq; Tulain, Ume Ruqia; Ayesha Rashid (Taylor and Francis Ltd., 2021)In this work, series of pH-responsive hydrogels (FMA1–FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery of an antiviral drug, acyclovir (ACV). Different proportions of β-cyclodextrin ...