Mimosa pudica mucilage nanoparticles of losartan potassium: Characterization and pharmacodynamics evaluation
Date
2023Item Type
ArticleAbstract
The current research was to develop nanoparticles based on Mimosa pudica mucilage (MPM) that could encapsulate losartan potassium (LP). Nanoparticles (NPs) produced through ionic-gelation method; the polymerization of the mucilage carried out using calcium chloride as cross-linking agent. The MPMLP-NPs demonstrated vastly enhanced pharmaceutical characteristics, presented discrete surface with spherical shape of 198.4–264.6 nm with PDI ranging 0.326–0.461 and entrapment efficiency was in the range of 80.65 ± 0.82–90.79 ± 0.96%. FTIR and DSC indicated the stability of drug during the formulation of nanoparticles. An acute oral toxicity investigation found no significant alterations in behavior and histopathology criteria. The MPMLP-NPs formulation revealed the better rates and sustained effect as assessed with the commercial product. Moreover, low dose of MPMLP-NPs showed similar anti-hypertensive effect as assessed with the marketed tablet.
Author
Ghumman, Shazia Akram
Mahmood, Arshad
Noreen, Sobia
Hameed, Huma
Kausar, Rizwana
Rana, Maria
Aslam, Asma