Latest submissions
Now showing items 81-100 of 149
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Synthesis and calcium channel blocking activity of 1, 4-dihydropyridine derivatives containing ester substitute and phenyl carbamoyl group
(Science Publications, 2011)Problem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester ... -
Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners
(MDPI AG., 2011)A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl ... -
Stress-driven discovery in the natural products: A gateway towards new drugs
(Elsevier Masson SAS., 2019)Elicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds ... -
Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives
(MDPI AG., 2011)A new series of 1,3-thiazole and benzo[d] thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as ... -
Bioequivalence assessment of two formulations of ibuprofen
(Dove Medical Press Ltd., 2011)Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz ®, produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was ... -
Anti-inflammatory agents of the carbamoylmethyl ester class: Synthesis, characterization, and pharmacological evaluation
(Dove Medical Press Ltd., 2013)In this study, target compounds 5-12 were synthesized via acid amine coupling of ibuprofen and naproxen with methyl ester derivatives of amino acids, namely, l-proline, sarcosine, l-tyrosine, and l-glutamic acid. When ... -
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties
(PubMed ID., 2013)A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)benzamides (1a-h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted ... -
Factors affecting the development of adverse drug reactions (Review article)
(Elsevier, 2013)Objectives: To discuss the effect of certain factors on the occurrence of Adverse Drug Reactions (ADRs). Data Sources: A systematic review of the literature in the period between 1991 and 2012 was made based on PubMed, the ... -
Experiential community pharmacy training: Assessment of students’ perceptions in the united arab emirates
(International Pharmaceutical Federation, 2020)Introduction: Community pharmacy settings provide places for promoting the effective and safe use of medicines all over the world. This study explored pharmacy students’ perceptions of the barriers they had faced during ... -
The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons
(Elsevier Inc., 2020)Cuscuta reflexa has been traditionally used as an antiemetic. Additionally, it has been used in various herbal formulations for the treatment of emesis. So far, there is no scientific evidence of the plant extract as ... -
Scale validation for the identification of falsified hand sanitizer: public and regulatory authorities perspectives from United Arab Emirates
(BioMed Central Ltd, 2020)Background: Since the time of declaration of global pandemic of COVID-19 by World Health Organization (WHO), falsified hand sanitizers surfaced regularly in markets, posing possible harm to public due to unlisted inclusion ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
(Taylor and Francis Ltd., 2015)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ... -
Survey data for COVID-19 vaccine preference analysis in the United Arab Emirates
(Elsevier Inc., 2020)In response to the call for interdisciplinary research on the potential effects of the coronavirus pandemic [1], this article presents a novel data set on individuals’ COVID-19 vaccine preferences in the United Arab Emirates ... -
Direct interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro
(Taylor and Francis Inc., 2016)Families of cyclin-like proteins have emerged that bind and activate cyclin dependent kinases (Cdk)s, directing the phosphorylation of noncanonical Cdk substrates. One of these proteins, Spy1, has demonstrated the unique ... -
COVID-19 Vaccine Development in a Quadruple Helix Innovation System: Uncovering the Preferences of the Fourth Helix in the UAE
(MDPI AG., 2020)Successful development and uptake of vaccine technology in a Quadruple Helix Innovative health or economic system requires a clear understanding of society’s preferences as the fourth helix. With significant financial ... -
Druggability analysis and classification of protein tyrosine phosphatase active sites
(Dove Medical Press Ltd., 2016)Protein tyrosine phosphatases (PTP) play important roles in the pathogenesis of many diseases. The fact that no PTP inhibitors have reached the market so far has raised many questions about their druggability. In this ... -
Evaluation of certain pharmaceutical quality attributes of lisinopril split tablets
(MDPI AG., 2016)Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical ... -
Formulation and Evaluation of Linum usitatissimum Mucilage-Based Nanoparticles for Effective Delivery of Ezetimibe
(Dove Medical Press Ltd., 2021)Introduction: The aim of current study was to prepare Linum usitatissimum mucilage (LUM) based nanoparticles, capable of encapsulating hydrophobic drug ezetimibe as nanocarriers. Methods: Solvent evaporation and nanoprecipitation ... -
What are the changes and burden associated with covid-19 in diabetes management and delivery of the diabetes services?
(Elmer Press, 2020)Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that has spread to almost all countries worldwide. Diabetes mellitus (DM) has been shown to increase the risk of COVID-19 disease severity. In this review, we ... -
Essential Medicines in Universal Health Coverage: A Scoping Review of Public Health Law Interventions and How They Are Measured in Five Middle-Income Countries
(MDPI AG., 2020)Very few studies exist of legal interventions (national laws) for essential medicines as part of universal health coverage in middle-income countries, or how the effect of these laws is measured. This study aims to critically ...