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Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia
(Hindawi Limited, 2018)
Aim: To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women ...
The evolving role of community pharmacists during COVID-19 in the UAE; assessing preparedness and knowledge
(Oxford University Press, 2021)
Objectives To investigate community pharmacists' knowledge about COVID-19 and their preparedness for the pandemic. Methods This cross-sectional online survey was conducted (in community pharmacies in the United Arab Emirates) ...
Kinetics of oxidation of atropine by K2Cr2O7 in acidic aqueous solutions
(Chemical Publishing Co., 2018)
Oxidation of atropine (ATN) by K2Cr2O7 has been studied kinetically in aqueous strongly acidic solutions. The kinetics of this reaction was investigated at different temperatures. A constant pH and constant ionic strength ...
Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy
(JMDGA., 2021)
Background Bone dysplasias are a large group of disorders affecting the growth and structure of the skeletal system. Methods In the present study, we report the clinical and molecular delineation of a new form of syndromic ...
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation
(Taylor and Francis Ltd., 2021)
In this work, series of pH-responsive hydrogels (FMA1–FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery of an antiviral drug, acyclovir (ACV). Different proportions of β-cyclodextrin ...
Characterization of human serum albumin's interactions with safranal and crocin using multi-spectroscopic and molecular docking techniques
(Elsevier B.V., 2019)
Interaction mechanisms of human serum albumin (HSA) with safranal and crocin were studied using UV–Vis absorption, fluorescence quenching and circular dichroism (CD) spectroscopies as well as molecular docking techniques. ...
Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
(BioMed Central, 2020)
Background: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric ...
Identification of new inhibitors of Mdm2-p53 interaction via pharmacophore and structure-based virtual screening
(Dove Medical Press Ltd., 2018)
Background: The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the ...
Anti-dengue, cytotoxicity, antifungal, and in silico study of the newly synthesized 3-O-Phospo-α-D-glucopyranuronic acid compound
(Hindawi., 2018)
The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance.The chemical structure of compound 7 (methyl 3-O-phospo-D-glucopyranuronic acid was elucidated by physical and ...
Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity
(John Wiley and Sons Ltd., 2018)
The presence of false positives in enzyme inhibition assays is a common problem in early drug discovery, especially for compounds that form colloid aggregates in solution. The molecular basis of these aggregates could not ...