Latest submissions
Now showing items 201-220 of 291
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In vitro and in vivo evaluation of oral controlled release formulation of bcs class i drug using polymer matrix system
(MDPI, 2021)Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high ... -
Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review
(Elsevier Masson s.r.l., 2021)Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials ... -
Gephyrin and cyp2c9 genetic polymorphisms in patients with pharmacoresistant epilepsy
(Dove Medical Press Ltd., 2021)Purpose: Gephyrin (GPHN) is an essential protein in the regulation of inhibitory postsy-naptic density and polymorphism in the corresponding gene may have a role in the development of pharmacoresistant epilepsy (PRE). For ... -
Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
(Elsevier B.V., 2021)The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of ... -
The investigation of energy management and atomic interaction between coronavirus structure in the vicinity of aqueous environment of H2O molecules via molecular dynamics approach
(Elsevier B.V., 2021)The coronavirus pandemic is caused by intense acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Identifying the atomic structure of this virus can lead to the treatment of related diseases in medical cases. In the ... -
Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease
(Sciendo, 2021)COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study is to target the SARS-CoV-2 ... -
A novel laparoscopic device for measuring gastrointestinal slow-wave activity
(Springer New York LLC., 2009)Background: A periodic electrical activity, termed "slow waves", coordinates gastrointestinal contractions. Slow-wave dysrhythmias are thought to contribute to dysmotility syndromes such as postoperative gastroparesis, but ... -
HPMC capsules: Current status and future prospects
(Canadian Society for Pharmaceutical Sciences., 2010)Hydroxypropyl methylcellulose (HPMC) is employed for a wide variety of pharmaceutical and food preparations. Its applications as viscolizing agent (thickening agent), coating polymer, bioadhesive, in solid dispersion to ... -
Synthesis and calcium channel blocking activity of 1, 4-dihydropyridine derivatives containing ester substitute and phenyl carbamoyl group
(Science Publications, 2011)Problem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester ... -
Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners
(MDPI AG., 2011)A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl ... -
Stress-driven discovery in the natural products: A gateway towards new drugs
(Elsevier Masson SAS., 2019)Elicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds ... -
Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives
(MDPI AG., 2011)A new series of 1,3-thiazole and benzo[d] thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as ... -
Bioequivalence assessment of two formulations of ibuprofen
(Dove Medical Press Ltd., 2011)Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz ®, produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was ... -
Anti-inflammatory agents of the carbamoylmethyl ester class: Synthesis, characterization, and pharmacological evaluation
(Dove Medical Press Ltd., 2013)In this study, target compounds 5-12 were synthesized via acid amine coupling of ibuprofen and naproxen with methyl ester derivatives of amino acids, namely, l-proline, sarcosine, l-tyrosine, and l-glutamic acid. When ... -
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties
(PubMed ID., 2013)A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)benzamides (1a-h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted ... -
Factors affecting the development of adverse drug reactions (Review article)
(Elsevier, 2013)Objectives: To discuss the effect of certain factors on the occurrence of Adverse Drug Reactions (ADRs). Data Sources: A systematic review of the literature in the period between 1991 and 2012 was made based on PubMed, the ... -
Experiential community pharmacy training: Assessment of students’ perceptions in the united arab emirates
(International Pharmaceutical Federation, 2020)Introduction: Community pharmacy settings provide places for promoting the effective and safe use of medicines all over the world. This study explored pharmacy students’ perceptions of the barriers they had faced during ... -
Characterization of protein complexes and subcomplexes in protein-protein interaction databases
(Hindawi Publishing Corporation, 2015)The identification and characterization of protein complexes implicated in protein-protein interaction data are crucial to the understanding of the molecular events under normal and abnormal physiological conditions. This ... -
On modeling of coronavirus-19 disease under Mittag-Leffler power law
(Springer, 2020)This paper investigates a new model on coronavirus-19 disease (COVID-19) with three compartments including susceptible, infected, and recovered class under Mittag-Leffler type derivative. The mentioned derivative has been ... -
The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons
(Elsevier Inc., 2020)Cuscuta reflexa has been traditionally used as an antiemetic. Additionally, it has been used in various herbal formulations for the treatment of emesis. So far, there is no scientific evidence of the plant extract as ...