Browsing Publications by Author "Sadek, Bassem"
Now showing items 1-6 of 6
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Anti-inflammatory agents of the carbamoylmethyl ester class: Synthesis, characterization, and pharmacological evaluation
Sadek, Bassem; Hamruoni, Amar Mansuor; Adem, Abdu (Dove Medical Press Ltd., 2013)In this study, target compounds 5-12 were synthesized via acid amine coupling of ibuprofen and naproxen with methyl ester derivatives of amino acids, namely, l-proline, sarcosine, l-tyrosine, and l-glutamic acid. When ... -
Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives
Sadek, Bassem; Al-Tabakha, Moawia Mohammed; Fahelelbom, Khairi Mustafa (MDPI AG., 2011)A new series of 1,3-thiazole and benzo[d] thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as ... -
Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder
Eissa, Nermin; Al-Houqani, Mohammed; Sadeq, Adel; Sasse, Astrid; Sadek, Bassem; Ojha, S.K. (Frontiers Media S.A., 2018)Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder characterized by two core behavioral symptoms, namely impairments in social communication and restricted/repetitive behavior. The molecular ... -
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties
Limban, Carmen; Missir, Alexandru Vasile; Fahelelbom, Khairi Mustafa; Al-Tabakha, Moawia Mohammed; Cǎproiu, Miron Teodor; Sadek, Bassem (PubMed ID., 2013)A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)benzamides (1a-h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted ... -
Synthesis and calcium channel blocking activity of 1, 4-dihydropyridine derivatives containing ester substitute and phenyl carbamoyl group
Sadek, Bassem; Fahelelbom, Khairi Mustafa; Moruşciag, Laurenţiu; Elz, Sigurd (Science Publications, 2011)Problem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester ... -
Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners
Sadek, Bassem; Fahelelbom, Khairi Mustafa (MDPI AG., 2011)A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl ...