Browsing Publications by Author "Fahelelbom, Khairi Mustafa"
Now showing items 1-10 of 10
-
Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives
Sadek, Bassem; Al-Tabakha, Moawia Mohammed; Fahelelbom, Khairi Mustafa (MDPI AG., 2011)A new series of 1,3-thiazole and benzo[d] thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as ... -
Evaluation of certain pharmaceutical quality attributes of lisinopril split tablets
Fahelelbom, Khairi Mustafa; Al-Tabakha, Moawia Mohammed; Eissa, Nermin; Javadi, Jeevani (MDPI AG., 2016)Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical ... -
First derivative ATR-FTIR spectroscopic method as a green tool for the quantitative determination of diclofenac sodium tablets
Fahelelbom, Khairi Mustafa; Saleh, Abdullah I.; Mansour, Ramez A.; Sayed, Sadik (F1000 Research, 2020)Background: Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a rapid quantitative method which has been applied for pharmaceutical analysis. This work describes the utility of first derivative ... -
Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy
Afreen, Urooj; Fahelelbom, Khairi Mustafa; Shah, Syed Nisar Hussain; Ashames, Akram; Almas, Uzma; Khan, Shujaat Ali; Yameen, Muhammad Arfat; Nisar, Naveed; Bin Asad, Muhammad Hassham Hassan; Murtaza, Ghulam (Taylor and Francis Ltd., 2022)Purpose of present study was to develop eight formulations of chlorpheniramine (CPM) niosomes according to 23 factorial design, characterise on the basis of various evaluation tests, i.e. in vitro drug release, SEM, FTIR, ... -
Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
Alotaibi, Badriyah Shadid; Pervaiz, Fahad; Buabeid, Manal; Ashames, Akram; Fahelelbom, Khairi Mustafa; Siddique, Sana; Shoukat, Hina; Rehman, Sadia; Noreen, Sobia; Murtaza, Ghulam (Elsevier B.V., 2021)The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of ... -
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties
Limban, Carmen; Missir, Alexandru Vasile; Fahelelbom, Khairi Mustafa; Al-Tabakha, Moawia Mohammed; Cǎproiu, Miron Teodor; Sadek, Bassem (PubMed ID., 2013)A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)benzamides (1a-h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted ... -
Quality attributes and in vitro bioequivalence of different brands of amoxicillin trihydrate tablets
Al-Tabakha, Moawia Mohammed; Fahelelbom, Khairi Mustafa; Obaid, Dana; Sayed, Sadik (MDPI AG., 2017)Bacterial resistance and antibiotic drug effectiveness can be related to administering generic products with a subtherapeutic dose or poor in vivo drug release. The aim of this study was to investigate whether locally ... -
Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: A brief review
Fahelelbom, Khairi Mustafa; Saleh, Abdullah; Al-Tabakha, Moawia M. A.; Ashames, Akram A. (Walter de Gruyter GmbH, 2022)Qualitative Fourier transform infrared (FTIR) spectroscopy has long been established and implemented in a wide variety of fields including pharmaceutical, biomedical, and clinical fields. While the quantitative applications ... -
Synthesis and calcium channel blocking activity of 1, 4-dihydropyridine derivatives containing ester substitute and phenyl carbamoyl group
Sadek, Bassem; Fahelelbom, Khairi Mustafa; Moruşciag, Laurenţiu; Elz, Sigurd (Science Publications, 2011)Problem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester ... -
Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners
Sadek, Bassem; Fahelelbom, Khairi Mustafa (MDPI AG., 2011)A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl ...