Browsing Publications by Author "Alzyoud, Lara"
Now showing items 1-4 of 4
-
Allosteric Binding Sites of the SARS-CoV-2 Main Protease: Potential Targets for Broad-Spectrum Anti-Coronavirus Agents
Alzyoud, Lara; Ghattas, Mohammad A.; Atatreh, Noor (Dove Medical Press Ltd, 2022)The current pandemic caused by the COVID-19 disease has reached everywhere in the world and has affected every aspect of our lives. As of the current data, the World Health Organization (WHO) has reported more than 300 ... -
Apolipoprotein E Genetic Variant and Blood Lipid Responses to Plant Sterols: A Systematic Review and Pooled Analysis of Clinical Trials
Abumweis, Suhad; Alzyoud, Lara; Alqadi, Sarah (Korean Society of Food Science and Nutrition, 2023-12)Plant sterols/stanols are effective cholesterol-lowering agents. However, it is unclear whether the apolipoprotein E (ApoE) genetic variants influence it. We investigated whether ApoE genetic variants modulate the responses ... -
The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation
Mahgoub, Radwa E.; Mohamed, Feda E.; Alzyoud, Lara; Ali, Bassam R.; Ferreira, Juliana; Rabeh, Wael M.; AlNeyadi, Shaikha S.; Atatreh, Noor; Ghattas, Mohammad A. (MDPI, 2022)The main protease enzyme (Mpro) of SARS-CoV-2 is one of the most promising targets for COVID-19 treatment. Accordingly, in this work, a structure-based virtual screening of 3.8 million ligand libraries was carried out. ... -
Structure–Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity
Farhat, Joviana; Alzyoud, Lara; Alwahsh, Mohammad; Al-Omari, Basem (MDPI, 2022)Benzofuran is a heterocyclic compound found naturally in plants and it can also be obtained through synthetic reactions. Multiple physicochemical characteristics and versatile features distinguish benzofuran, and its ...