Browsing Publications by Author "AbuRuz, Salahdein"
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Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Arafat, Mosab; Sarfraz, Muhammad; AbuRuz, Salahdein (MDPI AG., 2021)Sildenafil is the active substance in Viagra® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this ... -
Effect of Hydration Forms and Polymer Grades on Theophylline Controlled-Release Tablet: An Assessment and Evaluation
Sakkal, Molham; Arafat, Mosab; Yuvaraju, Priya; Beiram, Rami; Ali, Labeeb; Altarawneh, Mohammednoor; Hajamohideen, Abdul Razack; AbuRuz, Salahdein (Multidisciplinary Digital Publishing Institute (MDPI), 2024)Background: Drug release from controlled release delivery systems is influenced by various factors, including the polymer’s grade and the drug’s hydration form. This study aimed to investigate the impact of these factors ... -
In vitro and in vivo evaluation of oral controlled release formulation of bcs class i drug using polymer matrix system
Arafat, Mosab; Sarfraz, Muhammad; Bostanudin, Mohammad F.; Esmaeil, Anna; Salam, Aisha; AbuRuz, Salahdein (MDPI, 2021)Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high ... -
Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review
Arafat, Mosab; Sakkal, Molham; Beiram, Rami; AbuRuz, Salahdein (Multidisciplinary Digital Publishing Institute (MDPI), 2024-03)Cancer continues to pose one of the most critical challenges in global healthcare. Despite the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting and eliminating cancer cells while ... -
Preparation and Characterization of Theophylline Controlled Release Matrix System Incorporating Poloxamer 407, Stearyl Alcohol, and Hydroxypropyl Methylcellulose: A Novel Formulation and Development Study
Sakkal, Molham; Arafat, Mosab; Yuvaraju, Priya; Beiram, Rami; AbuRuz, Salahdein (Multidisciplinary Digital Publishing Institute (MDPI), 2024-03)Background: Theophylline (THN), a bronchodilator with potential applications in emerging conditions like COVID-19, requires a controlled-release delivery system due to its narrow therapeutic range and short half-life. This ...