Latest submissions
Now showing items 201-220 of 287
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Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease
(Sciendo, 2021)COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study is to target the SARS-CoV-2 ... -
A novel laparoscopic device for measuring gastrointestinal slow-wave activity
(Springer New York LLC., 2009)Background: A periodic electrical activity, termed "slow waves", coordinates gastrointestinal contractions. Slow-wave dysrhythmias are thought to contribute to dysmotility syndromes such as postoperative gastroparesis, but ... -
HPMC capsules: Current status and future prospects
(Canadian Society for Pharmaceutical Sciences., 2010)Hydroxypropyl methylcellulose (HPMC) is employed for a wide variety of pharmaceutical and food preparations. Its applications as viscolizing agent (thickening agent), coating polymer, bioadhesive, in solid dispersion to ... -
Synthesis and calcium channel blocking activity of 1, 4-dihydropyridine derivatives containing ester substitute and phenyl carbamoyl group
(Science Publications, 2011)Problem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester ... -
Synthesis, characterization, and antimicrobial evaluation of oxadiazole congeners
(MDPI AG., 2011)A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl ... -
Stress-driven discovery in the natural products: A gateway towards new drugs
(Elsevier Masson SAS., 2019)Elicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds ... -
Antimicrobial prospect of newly synthesized 1,3-thiazole derivatives
(MDPI AG., 2011)A new series of 1,3-thiazole and benzo[d] thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as ... -
Bioequivalence assessment of two formulations of ibuprofen
(Dove Medical Press Ltd., 2011)Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz ®, produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was ... -
Anti-inflammatory agents of the carbamoylmethyl ester class: Synthesis, characterization, and pharmacological evaluation
(Dove Medical Press Ltd., 2013)In this study, target compounds 5-12 were synthesized via acid amine coupling of ibuprofen and naproxen with methyl ester derivatives of amino acids, namely, l-proline, sarcosine, l-tyrosine, and l-glutamic acid. When ... -
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties
(PubMed ID., 2013)A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)benzamides (1a-h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted ... -
Factors affecting the development of adverse drug reactions (Review article)
(Elsevier, 2013)Objectives: To discuss the effect of certain factors on the occurrence of Adverse Drug Reactions (ADRs). Data Sources: A systematic review of the literature in the period between 1991 and 2012 was made based on PubMed, the ... -
Experiential community pharmacy training: Assessment of students’ perceptions in the united arab emirates
(International Pharmaceutical Federation, 2020)Introduction: Community pharmacy settings provide places for promoting the effective and safe use of medicines all over the world. This study explored pharmacy students’ perceptions of the barriers they had faced during ... -
Characterization of protein complexes and subcomplexes in protein-protein interaction databases
(Hindawi Publishing Corporation, 2015)The identification and characterization of protein complexes implicated in protein-protein interaction data are crucial to the understanding of the molecular events under normal and abnormal physiological conditions. This ... -
On modeling of coronavirus-19 disease under Mittag-Leffler power law
(Springer, 2020)This paper investigates a new model on coronavirus-19 disease (COVID-19) with three compartments including susceptible, infected, and recovered class under Mittag-Leffler type derivative. The mentioned derivative has been ... -
The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons
(Elsevier Inc., 2020)Cuscuta reflexa has been traditionally used as an antiemetic. Additionally, it has been used in various herbal formulations for the treatment of emesis. So far, there is no scientific evidence of the plant extract as ... -
An Authentic-Based Privacy Preservation Protocol for Smart e-Healthcare Systems in IoT
(IEEE., 2019)Emerging technologies rapidly change the essential qualities of modern societies in terms of smart environments. To utilize the surrounding environment data, tiny sensing devices and smart gateways are highly involved. It ... -
Scale validation for the identification of falsified hand sanitizer: public and regulatory authorities perspectives from United Arab Emirates
(BioMed Central Ltd, 2020)Background: Since the time of declaration of global pandemic of COVID-19 by World Health Organization (WHO), falsified hand sanitizers surfaced regularly in markets, posing possible harm to public due to unlisted inclusion ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
(Taylor and Francis Ltd., 2015)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ... -
Survey data for COVID-19 vaccine preference analysis in the United Arab Emirates
(Elsevier Inc., 2020)In response to the call for interdisciplinary research on the potential effects of the coronavirus pandemic [1], this article presents a novel data set on individuals’ COVID-19 vaccine preferences in the United Arab Emirates ... -
Direct interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro
(Taylor and Francis Inc., 2016)Families of cyclin-like proteins have emerged that bind and activate cyclin dependent kinases (Cdk)s, directing the phosphorylation of noncanonical Cdk substrates. One of these proteins, Spy1, has demonstrated the unique ...