Latest submissions
Now showing items 181-200 of 287
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Associations of pre-existing cardiovascular morbidity with severity and the fatality rate in COVID-19 patients: a systematic review and meta-analysis
(Korea Centers for Disease Control and Prevention, 2022)Objectives: The aim of this study was to evaluate the association of pre-existing cardiovascular comorbidities, including hypertension and coronary heart disease, with coronavirus disease 2019 (COVID-19) severity and ... -
Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies
(Elsevier B.V., 2022)Quince seed mucilage was used in a combination of sodium alginate to develop sustained-release microspheres of cefixime. Physical characterizations such as FTIR, TGA, DSC, and SEM were performed on the prepared microspheres. ... -
Recent Advances in Understanding the Structure and Function of the Human Microbiome
(Frontiers Media S.A., 2022)Trillions of microbes live within our bodies in a deep symbiotic relationship. Microbial populations vary across body sites, driven by differences in the environment, immunological factors, and interactions between microbial ... -
Amphiphilic Alkylated Pectin Hydrogels for Enhanced Topical Delivery of Fusidic Acid: Formulation and In Vitro Investigation
(MDPI, 2022)Hydrogels constructed of amphiphilically modified polysaccharides have attracted a lot of interest because of their potential to augment drug diffusion over the skin. This research describes the synthesis of amphiphilic ... -
Synthesis and Characterization of Carboxymethyl Chitosan Nanosponges with Cyclodextrin Blends for Drug Solubility Improvement
(MDPI, 2022)This study aimed to enhance the solubility and release characteristics of docetaxel by synthesizing highly porous and stimuli responsive nanosponges, a nano-version of hydrogels with the additional qualities of both hydrogels ... -
Enhanced Oral Bioavailability of Epalrestat SBE7-β-CD Complex Loaded Chitosan Nanoparticles: Preparation, Characterization and in-vivo Pharmacokinetic Evaluation
(NLM (Medline), 2021)Background: Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined. Purpose: Current research aimed to fabricate inclusion complexation of EPL ... -
Biofunctional Hyaluronic Acid/κ-Carrageenan InjectableHydrogels for Improved Drug Delivery and Wound Healing
(MDPI, 2022)The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers ... -
Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: A brief review
(Walter de Gruyter GmbH, 2022)Qualitative Fourier transform infrared (FTIR) spectroscopy has long been established and implemented in a wide variety of fields including pharmaceutical, biomedical, and clinical fields. While the quantitative applications ... -
Identification of vaccine and drug targets in Shigella dysenteriae sd197 using reverse vaccinology approach
(Nature Research, 2022)Shigellosis is characterized as diarrheal disease that causes a high mortality rate especially in children, elderly and immunocompromised patients. More recently, the World Health Organization advised safe vaccine designing ... -
Pharmacists-physicians collaborative intervention to reduce vaccine hesitancy and resistance: A randomized controlled trial
(Elsevier Ltd, 2022)Purpose: Given their negative influence on community health, vaccine hesitancy and resistance are emerging challenges that require healthcare intervention. Therefore, this study aimed to assess the impact of physician-pharmacist ... -
Berberine as a Potential Anticancer Agent:A Comprehensive Review
(MDPI, 2021)Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient ... -
Stress and its correlates among medical students in six medical colleges: an attempt to understand the current situation
(Springer Science and Business Media Deutschland GmbH, 2021)Abstract: Background: Medical students encounter various stressors during their studies. The study aimed to assess stress levels, sources, and associated determinants among Sudanese medical students. An online questionnaire-based ... -
An assessment of the interaction between studying pharmacy, problematic use of social media and depression
(American Association of Colleges of Pharmacy, 2021)Social media applications are widely used across different age groups and communities. Problematic use of social media (PMSU) is associated with depression among university students. There is a lack of data regarding the ... -
New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)
(Frontiers Media S.A., 2021)Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the in vitro and in vivo models of epilepsy to probe the ... -
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on in Vivo Pharmacological Effects and Bioavailability Traits
(Hindawi Limited, 2021)Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing ... -
In vitro and in vivo evaluation of oral controlled release formulation of bcs class i drug using polymer matrix system
(MDPI, 2021)Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high ... -
Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review
(Elsevier Masson s.r.l., 2021)Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials ... -
Gephyrin and cyp2c9 genetic polymorphisms in patients with pharmacoresistant epilepsy
(Dove Medical Press Ltd., 2021)Purpose: Gephyrin (GPHN) is an essential protein in the regulation of inhibitory postsy-naptic density and polymorphism in the corresponding gene may have a role in the development of pharmacoresistant epilepsy (PRE). For ... -
Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
(Elsevier B.V., 2021)The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of ... -
The investigation of energy management and atomic interaction between coronavirus structure in the vicinity of aqueous environment of H2O molecules via molecular dynamics approach
(Elsevier B.V., 2021)The coronavirus pandemic is caused by intense acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Identifying the atomic structure of this virus can lead to the treatment of related diseases in medical cases. In the ...