Latest submissions
Now showing items 21-40 of 147
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Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)The traditional use of Mirabilis jalapa L. roots to enhance male sexual performance prompted us to assess the in silico, in vitro, and in vivo aphrodisiac activities of its hydroethanolic extract using normal male rats. ... -
Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)Mangiferin (MGF), a xanthone derived from Mangifera indica L., initially employed as a nutraceutical, is now being explored extensively for its anticancer potential. Scientists across the globe have explored this bioactive ... -
Exploring the gelling properties of Plantago ovata-based Arabinoxylan: Fabrication and optimization of a topical emulgel using response surface methodology
(NLM (Medline), 2023)Prime objective of the current research was to develop a stable nimesulide emulgel with the help of arabinoxylan, a natural gelling agent extracted from Plantago ovata. The response surface methodology was used by a Design ... -
Validation of a Cost-Effective RP-HPLC Method for Quantitative Investigation of Daclatasvir Dihydrochloride in Pharmaceutical Formulations
(Hindawi Limited, 2023)A well-known direct-acting antiviral (DAA) drug called daclatasvir may be used to treat chronic hepatitis C virus (HCV) infection. Herein, we reported a selective, precise, and a cost-effective analytical method for the ... -
Investigating the effect of basic amino acids and glucosamine on the solubility of ibuprofen and piroxicam
(Tabriz University of Medical Sciences, 2023)Purpose: Poor aqueous solubility hampers the development of several compounds as pharmacological agents. Hence, preparing novel formulations with augmented absorption is a challenge in pharmaceutical industries. In this ... -
Recent advances in the development of sialyltransferase inhibitors to control cancer metastasis: A comprehensive review
(Elsevier Masson s.r.l., 2023)Metastasis accounts for the majority of cancer-associated mortalities, representing a huge health and economic burden. One of the mechanisms that enables metastasis is hypersialylation, characterized by an overabundance ... -
Scrophularia peyronii Post. from Jordan: Chemical Composition of Essential Oil and Phytochemical Profiling of Crude Extracts and Their In Vitro Antioxidant Activity
(MDPI, 2023)The genus Scrophularia is one of the largest genera belonging to the Scrophulariaceae family. Different members of the genus exhibit an interesting, wide spectrum of bioactivities. Accordingly, the current study aimed to ... -
Construction of Te-ZnO@S-g-C3N4Heterojunction Nanocomposites for the Efficient Removal of Methylene Blue, Antifungal Activity, and Adsorption of Cr(VI) Ion
(Hindawi Limited, 2023)Heterojunctions have proven to be effective catalysts for removing organic pollutants and heavy metals from wastewater. The following study is also about the formation of 2D heterojunction tellurium-doped zinc oxide composite ... -
Pharmacokinetic interaction of rosuvastatin with artichoke (Cynara scolymusL.) leaf extract in rats
(Open Science Publishers LLP Inc., 2023)Dyslipidemia is a prevalent disease among the international population that has substantially increased, which can be treated with several hypolipidemic drugs such as rosuvastatin. Artichoke is a plant that is commonly ... -
Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software
(Frontiers Media S.A., 2023)Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore ... -
High throughput biochemical profiling, and functional potential analysis for valorization of grape peduncles
(Nature Research, 2023)Vitis vinifera L., commonly known as grape is a major fruit crop in the world. Grapes seem to confer health benefits due to their chemical components, biological and antioxidant activities. The present study is conducted ... -
Effect of Excipients on the Quality of Drug Formulation and Immediate Release of Generic Metformin HCl Tablets
(MDPI, 2023)Generic medications are bioequivalent to brand-name medications, but the quality and purity of generic medications are still debatable. The aim of this study was to compare the generic product of metformin (MET) to its ... -
Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors
(MDPI, 2023)The need for new antibiotics has become a major worldwide challenge as bacterial strains keep developing resistance to the existing drugs at an alarming rate. Enoyl-acyl carrier protein reductases (FabI) play a crucial ... -
The usage pattern of patients’ drug information leaflet for oral non-prescription drugs among university students in the United Arab Emirates: cross-sectional study
(Grupo de Investigacion en Atencion Farmaceutica, 2023)Background: Very few extensive studies have measured the prevalence and usage pattern of drug information leaflet (DIL) for oral non-prescription drugs (ONPDs) or identified the associated risk factors for not reading DIL ... -
Synthesis, molecular docking and ADMET studies of bis-benzimidazole-based thiadiazole derivatives as potent inhibitors, in vitro α-amylase and α-glucosidase
(Elsevier B.V., 2023)Different research synthetic methods have been developed recently for the synthesis of bis-benzimidazole analogs to investigate various biological significances. In this present study, an attempt was made to synthesize a ... -
Medication errors in relation to direct-acting oral anticoagulants: a qualitative study of pharmacists’ views and experiences
(Springer Science and Business Media Deutschland GmbH, 2023)Background: Despite their effectiveness and ease of use, medication errors have been reported to be highly prevalent with direct-acting oral anticoagulants (DOAC). Aim: The aim of this study was to explore views and ... -
Enhanced Intestinal Permeability of Cefixime by Self-Emulsifying Drug Delivery System: In-Vitro and Ex-Vivo Characterization
(NLM (Medline), 2023)BACKGROUND: Cefixime (CFX) belongs to a group of third-generation cephalosporin antibiotics with low water solubility and low intestinal permeability, which ultimately leads to significantly low bioavailability. AIM: This ... -
Assessment of Knowledge, Perception, Experience and Phobia toward Corticosteroids Use among the General Public in the Era of COVID-19: A Multinational Study
(MDPI, 2023)Background: Corticosteroids play a significant role in managing the vast majority of inflammatory and immunologic conditions. To date, population-based studies on knowledge and attitudes concerning corticosteroids are ... -
Applying medicines reconciliation indicators in two UK hospitals: a feasibility study
(Oxford University Press, 2021)ObjectivesThe aim of this study was to apply the Medicines reconciliation (MR) indicators and to assess their feasibility for use with patients on admission. MethodsThis is a mixed-methods study conducted in two large ... -
Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitors
(NLM (Medline), 2023)Deposition of hydroxyapatite (HA) or alkaline phosphate crystals on soft tissues causes the pathological calcification diseases comprising of end-stage osteoarthritis (OA), ankylosing spondylitis (AS), medial artery ...