استعرض Pharmaceutical Sciences حسب المؤلف "Sarfraz, Muhammad"
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Carbopol Based Hydrogels for ITOPRIDE Hydrochloride Delivery; Synthesis, Characterization and Comparative Assessment with Various Monomers
Sarfraz, Muhammad; Iqbal, Rabia; Khan, Kifayat Ullah; Minhas, Muhammad Usman (MDPI, 2022)The objective of the current study was to synthesize and characterize carbopol containing hydrogels with different monomers such as methacrylic acid (MAA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and itaconic ... -
Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery—In Vitro and In Vivo Evaluation
Sarfraz, Muhammad; Tulain, Ume Ruqia; Erum, Alia; Malik, Nadia Shamshad; Mahmood, Arshad; Sumaira, S.; Aslam, Sidra; Sandhu, Mansur Abdullah; Tayyab, Muhammad (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The primary objective of this study was to assess the potential utility of quince seed mucilage as an excipient within a graft copolymer for the development of an oral-controlled drug delivery system. The Cydonia ... -
Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Arafat, Mosab; Sarfraz, Muhammad; AbuRuz, Salahdein (MDPI AG., 2021)Sildenafil is the active substance in Viagra® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this ... -
Development of Niacinamide/Ferulic Acid-Loaded Multiple Emulsion and Its In Vitro/In Vivo Investigation as a Cosmeceutical Product
Huma, Sidra; Khan, Haji Muhammad Shoaib; Ijaz, Shakeel; Sarfraz, Muhammad; Zaka, Hafiz Saqib; Ahmad, Aousaf (NLM (Medline), 2022)Objective: Multiple emulsions have the ability to incorporate both lipophilic and hydrophilic actives in the same preparation and facilitate permeation of active ingredients through skin. The current study was aimed at ... -
Enhanced Antidepressant Activity of Nanostructured Lipid Carriers Containing Levosulpiride in Behavioral Despair Tests in Mice
Arif, Sadia Tabassam; Khan, Muhammad Ayub; Zaman, Shahiq uz; Sarwar, Hafiz Shoaib; Raza, Abida; Sarfraz, Muhammad; Bin Jardan, Yousef A.; Amin, Muhammad Umair; Sohail, Muhammad Farhan (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The potential of levosulpiride-loaded nanostructured lipid carriers (LSP-NLCs) for enhanced antidepressant and anxiolytic effects was evaluated in the current study. A forced swim test (FST) and tail suspension test (TST) ... -
Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats
Rahman, Asad Ur; Alam, Fiaz; Khan, Muhammad; Sarfraz, Muhammad; Basit, Abdul; Ahmad, Tawseef; Khokhar, Muhammad Ali; Ali, Sayyad; Khan, Kifayat Ullah (Multidisciplinary Digital Publishing Institute (MDPI), 2023)The traditional use of Mirabilis jalapa L. roots to enhance male sexual performance prompted us to assess the in silico, in vitro, and in vivo aphrodisiac activities of its hydroethanolic extract using normal male rats. ... -
Evaluation of anticancer potential of tetracene-5,12-dione (A01) and pyrimidine-2,4-dione (A02) via caspase 3 and lactate dehydrogenase cytotoxicity investigations
Aziz, Mubashir; Sarfraz, Muhammad; Ibrahim, Muhammad Khurrum; Ejaz, Syeda Abida; Zehra, Tasneem; Ogaly, Hanan A.; Arafat, Mosab; Al-Zahrani, Fatimah A.M.; Li, Chen (Public Library of Science, 2023-12)Cancer stands as a significant global cause of mortality, predominantly arising from the dysregulation of key enzymes and DNA. One strategic avenue in developing new anticancer agents involves targeting specific proteins ... -
Fabrication, organoleptic evaluation and in vitro characterization of cream loaded with Carica papaya seed extract
Sarfraz, Muhammad; Shabbir, Kanwal; Adnan, Qazi; Khan, Haji Muhammad Shoaib; Shirazi, Jafir Hussain; Sabir, Hamna; Mehmood, Nimrah; Bin Jardan, Yousef A.; Khan, Kifayat Ullah; Basit, Abdul (John Wiley and Sons Inc, 2023)Objective: The current study aimed to provide preliminary insights into potential biopharmaceutical applications of Carica papaya seed extract by evaluating its phytochemical and biological profiles. Furthermore, the study ... -
In vitro and in vivo evaluation of oral controlled release formulation of bcs class i drug using polymer matrix system
Arafat, Mosab; Sarfraz, Muhammad; Bostanudin, Mohammad F.; Esmaeil, Anna; Salam, Aisha; AbuRuz, Salahdein (MDPI, 2021)Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high ... -
Investigating the effect of basic amino acids and glucosamine on the solubility of ibuprofen and piroxicam
Valizadeh, Hadi; Mahdinloo, Somayeh; Zakeri, Negin; Sarfraz, Muhammad; Nezafat, Saeed; Zakeri-Milani, Parvin (Tabriz University of Medical Sciences, 2023)Purpose: Poor aqueous solubility hampers the development of several compounds as pharmacological agents. Hence, preparing novel formulations with augmented absorption is a challenge in pharmaceutical industries. In this ... -
Nano-Formulation Based Intravesical Drug Delivery Systems: An Overview of Versatile Approaches to Improve Urinary Bladder Diseases
Sarfraz, Muhammad; Qamar, Shaista; Rehman, Masood Ur; Tahir, Muhammad Azam; Ijaz, Muhammad; Ahsan, Anam; Asim, Mulazim Hussain; Nazir, Imran (MDPI, 2022)Intravesical drug delivery is a direct drug delivery approach for the treatment of various bladder diseases. The human urinary bladder has distinctive anatomy, making it an effective barrier against any toxic agent seeking ... -
Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy
Sarfraz, Muhammad; Khan, Abida; Batiha, Gaber El-Saber; Akhtar, Muhammad Furqan; Saleem, Ammara; Ajiboye, Basiru Olaitan; Kamal, Mehnaz; Ali, Abuzer; Alotaibi, Nawaf M.; Aaghaz, Shams; Siddique, Muhammad Irfan; Imran, Mohd (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Mangiferin (MGF), a xanthone derived from Mangifera indica L., initially employed as a nutraceutical, is now being explored extensively for its anticancer potential. Scientists across the globe have explored this bioactive ... -
Papain-Decorated Mucopenetrating SEDDS: A Tentative Approach to Combat Absorption Issues of Acyclovir via the Oral Route
Mahmood, Arshad; Haneef, Rabbia; Al Meslamani, Ahmad Z.; Bostanudin, Mohammad F.; Sohail, Muhammad; Sarfraz, Muhammad; Arafat, Mosab (MDPI, 2022)The aim of the current study was to enhance the oral bioavailability of Acyclovir (ACV) based on the papain-functionalized self-emulsifying drug delivery systems (SEDDS). The optimum control SEDDS formulation comprised of ... -
Phytochemical profiling, antioxidant and antiproliferation potential of Euphorbia milii var.: Experimental analysis and in-silico validation
Chohan, Talha Ali; Sarfraz, Muhammad; Rehman, Kanwal; Muhammad, Tariq; Ghori, Muhammad Usman; Khan, Kashif Maqbool; Afzal, Iftikhar; Akash, Muhammad Sajid Hamid; Alamgeer; Malik, Arif; Chohan, T.A. (Elsevier B.V., 2020)This study was aimed to investigate the anticancer potential of Euphorbia milii (E. milii) using an exquisite combination of phytopharmacological and advanced computational techniques. The chloroform fraction (Em-C) of E. ... -
Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug's Solubility Improvement
Minhas, Muhammad Usman; Khan, Kifayat Ullah; Sarfraz, Muhammad; Badshah, Syed Faisal; Munir, Abubakar; Barkat, Kashif; Basit, Abdul; Arafat, Mosab (NLM (Medline), 2022)Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately ... -
Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
Rashid, Memoona; Sarfraz, Muhammad; Arafat, Mosab; Hussain, Amjad; Abbas, Nasir; Sadiq, Muhammad Waqas; Rasool, Muhammad Fawad; Bukhari, Nadeem Irfan (BioMed Central, 2020)Background: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric ... -
Secondary metabolites profiling, biological activities and computational studies of Abutilon figarianum webb (Malvaceae)
Saleem, Hammad; Sarfraz, Muhammad; Ahsan, Hafiz Muhammad; Khurshid, Umair; Kazmi, Syed Asif Jahanzeb; Zengin, Gokhan; Locatelli, Marcello; Ahmad, Irshad; Abdallah, Hassan H.; Mahomoodally, Mohamad Fawzi; Rengasamy, Kannan RR.; Ahemad, Nafees (MDPI AG., 2020)This research endeavors to inspect the chemical and biological profiling of methanol anddichloromethane (DCM) extracts prepared fromAbutilon figarianumWebb. Total bioactive constituentsand secondary metabolites were ... -
Synthesis and Evaluation of Finasteride-Loaded HPMC-Based Nanogels for Transdermal Delivery: A Versatile Nanoscopic Platform
Ahmad, Aousaf; Ahmad, Mahmood; Minhas, Muhammad Usman; Sarfraz, Muhammad; Sohail, Muhammad; Khan, Kifayat Ullah; Tanveer, Sana; Ijaz, Shakeel (NLM (Medline), 2022)Herein, we report nanogels comprising diverse feed ratio of polymer hydroxypropyl methylcellulose (HPMC), monomer acrylic acid (AA), and cross-linker methylene bisacrylamide (MBA) fabricated for transdermal delivery of ... -
Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitors
Mustafa, Muhammad Naeem; Channar, Pervaiz Ali; Sarfraz, Muhammad; Saeed, Aamer; Ejaz, Syeda Abida; Aziz, Mubashir; Alasmary, Fatmah Ali; Alsoqair, Hanadi Yaqob; Raza, Hussain; Kim, Song Ja; Hamad, Asad (NLM (Medline), 2023)Deposition of hydroxyapatite (HA) or alkaline phosphate crystals on soft tissues causes the pathological calcification diseases comprising of end-stage osteoarthritis (OA), ankylosing spondylitis (AS), medial artery ...