Browsing Pharmaceutical Sciences by Author "Arafat, Mosab"
Now showing items 1-15 of 15
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Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists in Lahore, Punjab, Pakistan
Sarwar, Muhammad Rehan; Saqib, Anum; Riaz, Tayyab; Aziz, Haleema; Arafat, Mosab; Nouman, Hamna (Public Library of Science, 2018)Background and objectives Practice-based research (PBR) is of pivotal importance for hospital pharmacists which not only up-grades the profession but also improves the patient care. This study aimed to evaluate the attitude, ... -
Butylglyceryl pectin nanoparticles: Synthesis, formulation and characterization
Bostanudin, Mohammad F.; Arafat, Mosab; Sarfraz, Muhammad K.; Gôrecki, Dariusz C.; Barbu, Eugen (MDPI AG., 2019)Pectin is a polysaccharide with very good gel forming properties that traditionally has found important applications in foods and pharmaceutical industries. Although less studied, chemical modifications of pectin leading ... -
Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Arafat, Mosab; Sarfraz, Muhammad; AbuRuz, Salahdein (MDPI AG., 2021)Sildenafil is the active substance in Viagra® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this ... -
Effect of Excipients on the Quality of Drug Formulation and Immediate Release of Generic Metformin HCl Tablets
Arafat, Mosab; Sakkal, Molham; Yuvaraju, Priya; Esmaeil, Anna; Poulose, Vijo; Aburuz, Salahdein (MDPI, 2023)Generic medications are bioequivalent to brand-name medications, but the quality and purity of generic medications are still debatable. The aim of this study was to compare the generic product of metformin (MET) to its ... -
Effect of Hydration Forms and Polymer Grades on Theophylline Controlled-Release Tablet: An Assessment and Evaluation
Sakkal, Molham; Arafat, Mosab; Yuvaraju, Priya; Beiram, Rami; Ali, Labeeb; Altarawneh, Mohammednoor; Hajamohideen, Abdul Razack; AbuRuz, Salahdein (Multidisciplinary Digital Publishing Institute (MDPI), 2024)Background: Drug release from controlled release delivery systems is influenced by various factors, including the polymer’s grade and the drug’s hydration form. This study aimed to investigate the impact of these factors ... -
Evaluation of anticancer potential of tetracene-5,12-dione (A01) and pyrimidine-2,4-dione (A02) via caspase 3 and lactate dehydrogenase cytotoxicity investigations
Aziz, Mubashir; Sarfraz, Muhammad; Ibrahim, Muhammad Khurrum; Ejaz, Syeda Abida; Zehra, Tasneem; Ogaly, Hanan A.; Arafat, Mosab; Al-Zahrani, Fatimah A.M.; Li, Chen (Public Library of Science, 2023-12)Cancer stands as a significant global cause of mortality, predominantly arising from the dysregulation of key enzymes and DNA. One strategic avenue in developing new anticancer agents involves targeting specific proteins ... -
In vitro and in vivo evaluation of oral controlled release formulation of bcs class i drug using polymer matrix system
Arafat, Mosab; Sarfraz, Muhammad; Bostanudin, Mohammad F.; Esmaeil, Anna; Salam, Aisha; AbuRuz, Salahdein (MDPI, 2021)Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high ... -
Nano-sized droplets of self-emulsifying system for enhancing oral bioavailability of chemotherapeutic agent VP-16 in rats: A nano lipid carrier for BCS class IV drugs
Khalid, Nayab; Sarfraz, Muhammad K.; Arafat, Mosab; Akhtar, Muhammad; Löbenberg, Raimar; Nisar-Ur-Rahman (Canadian Society for Pharmaceutical Sciences., 2018)PURPOSE: The purpose of this study was to investigate the ability of a self-nano-emulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of a BCS class IV drug, etoposide (VP-16). METHOD: A series of ... -
Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review
Arafat, Mosab; Sakkal, Molham; Beiram, Rami; AbuRuz, Salahdein (Multidisciplinary Digital Publishing Institute (MDPI), 2024-03)Cancer continues to pose one of the most critical challenges in global healthcare. Despite the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting and eliminating cancer cells while ... -
Nanosized liposomes containing bile salt: A vesicular nanocarrier for enhancing oral bioavailability of BCS class III drug
Arafat, Mosab; Kirchhoefer, Cathrin; Mikov, Momir M.; Sarfraz, Muhammad K.; Löbenberg, Raimar (Canadian Society for Pharmaceutical Sciences, 2017)PURPOSE: Liposomes have been studied as a colloidal carrier in drug delivery systems, especially for oral administration. However, their low structural integrity in the gut is still a major shortcoming. Membrane disruptive ... -
Papain-Decorated Mucopenetrating SEDDS: A Tentative Approach to Combat Absorption Issues of Acyclovir via the Oral Route
Mahmood, Arshad; Haneef, Rabbia; Al Meslamani, Ahmad Z.; Bostanudin, Mohammad F.; Sohail, Muhammad; Sarfraz, Muhammad; Arafat, Mosab (MDPI, 2022)The aim of the current study was to enhance the oral bioavailability of Acyclovir (ACV) based on the papain-functionalized self-emulsifying drug delivery systems (SEDDS). The optimum control SEDDS formulation comprised of ... -
Polyvinylpyrrolidone K-30-Based Crosslinked Fast Swelling Nanogels: An Impeccable Approach for Drug's Solubility Improvement
Minhas, Muhammad Usman; Khan, Kifayat Ullah; Sarfraz, Muhammad; Badshah, Syed Faisal; Munir, Abubakar; Barkat, Kashif; Basit, Abdul; Arafat, Mosab (NLM (Medline), 2022)Poor solubility is a global issue of copious pharmaceutical industries as large number of drugs in development stage as well as already marketed products are poorly soluble which results in low dissolution and ultimately ... -
Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
Rashid, Memoona; Sarfraz, Muhammad; Arafat, Mosab; Hussain, Amjad; Abbas, Nasir; Sadiq, Muhammad Waqas; Rasool, Muhammad Fawad; Bukhari, Nadeem Irfan (BioMed Central, 2020)Background: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric ... -
Preparation and Characterization of Theophylline Controlled Release Matrix System Incorporating Poloxamer 407, Stearyl Alcohol, and Hydroxypropyl Methylcellulose: A Novel Formulation and Development Study
Sakkal, Molham; Arafat, Mosab; Yuvaraju, Priya; Beiram, Rami; AbuRuz, Salahdein (Multidisciplinary Digital Publishing Institute (MDPI), 2024-03)Background: Theophylline (THN), a bronchodilator with potential applications in emerging conditions like COVID-19, requires a controlled-release delivery system due to its narrow therapeutic range and short half-life. This ... -
Transdermal patches: Design and current approaches to painless drug delivery
Al-Hanbali, Othman A.R.; Khan, Hajji Muhammad Shoaib; Sarfraz, Muhammad K.; Arafat, Mosab; Ijaz, Shakeel; Hameed, Abdul (Sciendo, 2019)Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug hydrolysis and degradation in acidic media, drug fluctuations, ...