Browsing Pharmaceutical Sciences by Issue Date
Now showing items 61-80 of 148
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The Compulsory Licensing for Exploiting Patented COVID-19 Pharmaceutical Treatment: Legal Approaches of Some Arab Countries.
(Mary Ann Liebert Inc., 2021)This article deals with exploitation of a pharmaceutical patent to treat the novel coronavirus. The laws of several Arab nations, which regulate industrial property rights in regard to the use of compulsory licensing for ... -
Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
(MDPI AG., 2021)Sildenafil is the active substance in Viagra® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this ... -
Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease
(Sciendo, 2021)COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study is to target the SARS-CoV-2 ... -
Formulation and Evaluation of Linum usitatissimum Mucilage-Based Nanoparticles for Effective Delivery of Ezetimibe
(Dove Medical Press Ltd., 2021)Introduction: The aim of current study was to prepare Linum usitatissimum mucilage (LUM) based nanoparticles, capable of encapsulating hydrophobic drug ezetimibe as nanocarriers. Methods: Solvent evaporation and nanoprecipitation ... -
A quantitative evaluation of evidence-based beliefs and implementation among community pharmacists: Findings and impact from United Arab Emirates
(Dove Medical Press Ltd., 2021)Background: The flux of pharmaceutical data can have a negative impact on the complexity of a pharmacist’s decision-making process, which will demand an extensive evaluation from healthcare providers trying to choose the ... -
How to face COVID-19: proposed treatments based on remdesivir and hydroxychloroquine in the presence of zinc sulfate. Docking/DFT/POM structural analysis
(Taylor and Francis Ltd., 2021)Remdesivir and hydroxychloroquine derivatives form two important classes of heterocyclic compounds. They are known for their anti-malarial biological activity. This research aims to analyze the physicochemical properties ... -
The evolving role of community pharmacists during COVID-19 in the UAE; assessing preparedness and knowledge
(Oxford University Press, 2021)Objectives To investigate community pharmacists' knowledge about COVID-19 and their preparedness for the pandemic. Methods This cross-sectional online survey was conducted (in community pharmacies in the United Arab Emirates) ... -
Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy
(JMDGA., 2021)Background Bone dysplasias are a large group of disorders affecting the growth and structure of the skeletal system. Methods In the present study, we report the clinical and molecular delineation of a new form of syndromic ... -
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation
(Taylor and Francis Ltd., 2021)In this work, series of pH-responsive hydrogels (FMA1–FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery of an antiviral drug, acyclovir (ACV). Different proportions of β-cyclodextrin ... -
iOntoBioethics: A Framework for the Agile Development of Bioethics Ontologies in Pandemics, Applied to COVID-19
(Frontiers Media S.A., 2021)Background: Few ontological attempts have been reported for conceptualizing the bioethics domain. In addition to limited scope representativeness and lack of robust methodological approaches in driving research design and ... -
Online medication purchasing during the Covid-19 pandemic: A pilot study from the United Arab Emirates
(Springer, 2021)Abstract Background: Since the WHO announced that Covid-19 had become a global pandemic, online pharmacies have emerged as an extremely popular way to purchase medication due to the quarantine measures introduced by ... -
Nanostructured lipid carriers based suppository for enhanced rectal absorption of ondansetron: In vitro and in vivo evaluations
(Elsevier B.V., 2021)The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of ... -
Gephyrin and cyp2c9 genetic polymorphisms in patients with pharmacoresistant epilepsy
(Dove Medical Press Ltd., 2021)Purpose: Gephyrin (GPHN) is an essential protein in the regulation of inhibitory postsy-naptic density and polymorphism in the corresponding gene may have a role in the development of pharmacoresistant epilepsy (PRE). For ... -
Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review
(Elsevier Masson s.r.l., 2021)Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials ... -
In vitro and in vivo evaluation of oral controlled release formulation of bcs class i drug using polymer matrix system
(MDPI, 2021)Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high ... -
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on in Vivo Pharmacological Effects and Bioavailability Traits
(Hindawi Limited, 2021)Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing ... -
New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)
(Frontiers Media S.A., 2021)Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the in vitro and in vivo models of epilepsy to probe the ... -
Berberine as a Potential Anticancer Agent:A Comprehensive Review
(MDPI, 2021)Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient ... -
Enhanced Oral Bioavailability of Epalrestat SBE7-β-CD Complex Loaded Chitosan Nanoparticles: Preparation, Characterization and in-vivo Pharmacokinetic Evaluation
(NLM (Medline), 2021)Background: Epalrestat (EPL) is a carboxylic acid derivative with poor aqueous solubility and its pharmacokinetic features are not fully defined. Purpose: Current research aimed to fabricate inclusion complexation of EPL ... -
Applying medicines reconciliation indicators in two UK hospitals: a feasibility study
(Oxford University Press, 2021)ObjectivesThe aim of this study was to apply the Medicines reconciliation (MR) indicators and to assess their feasibility for use with patients on admission. MethodsThis is a mixed-methods study conducted in two large ...