Browsing Pharmaceutical Sciences by Issue Date
Now showing items 21-40 of 146
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Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia
(Hindawi Limited, 2018)Aim: To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women ... -
Kinetics of oxidation of atropine by K2Cr2O7 in acidic aqueous solutions
(Chemical Publishing Co., 2018)Oxidation of atropine (ATN) by K2Cr2O7 has been studied kinetically in aqueous strongly acidic solutions. The kinetics of this reaction was investigated at different temperatures. A constant pH and constant ionic strength ... -
Identification of new inhibitors of Mdm2-p53 interaction via pharmacophore and structure-based virtual screening
(Dove Medical Press Ltd., 2018)Background: The tumor suppressor protein p53 plays an important role in preventing tumor formation and progression through its involvement in cell division control and initiation of apoptosis. Mdm2 protein controls the ... -
Anti-dengue, cytotoxicity, antifungal, and in silico study of the newly synthesized 3-O-Phospo-α-D-glucopyranuronic acid compound
(Hindawi., 2018)The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance.The chemical structure of compound 7 (methyl 3-O-phospo-D-glucopyranuronic acid was elucidated by physical and ... -
Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity
(John Wiley and Sons Ltd., 2018)The presence of false positives in enzyme inhibition assays is a common problem in early drug discovery, especially for compounds that form colloid aggregates in solution. The molecular basis of these aggregates could not ... -
Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists in Lahore, Punjab, Pakistan
(Public Library of Science, 2018)Background and objectives Practice-based research (PBR) is of pivotal importance for hospital pharmacists which not only up-grades the profession but also improves the patient care. This study aimed to evaluate the attitude, ... -
Bioavailability of beclometasone from two hfa-bdp formulations with a spacer
(American Association for Respiratory, 2019)BACKGROUND: The drug delivery characteristics of each inhaler/spacer combination are unique. The spacer size as well as the presence of electrostatic charge greatly influence the inhaler dose emission and in vivo delivery. ... -
Medicines policy issues for Saudi Arabia: priorities and model
(Blackwell., 2019)The Kingdom of Saudi Arabia (KSA) has a population of 32.6 million in 2018, with a growth rate of 2.65% per annum. In World Health Organization's ranking, WHO has ranked Saudi Arabia at 26 among 191 countries for the ... -
Stress-driven discovery in the natural products: A gateway towards new drugs
(Elsevier Masson SAS., 2019)Elicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds ... -
Luteolin, a flavonoid, as an anticancer agent: A review
(Elsevier Masson SAS., 2019)Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal ... -
Butylglyceryl pectin nanoparticles: Synthesis, formulation and characterization
(MDPI AG., 2019)Pectin is a polysaccharide with very good gel forming properties that traditionally has found important applications in foods and pharmaceutical industries. Although less studied, chemical modifications of pectin leading ... -
Proanthocyanidins: A comprehensive review
(Elsevier Masson SAS., 2019)Proanthocyanidins are condensed tannins with various pharmacological properties. These phytochemicals are considered as ‘offense and defense molecules because of their human health benefits. The validation of their diverse ... -
Transdermal patches: Design and current approaches to painless drug delivery
(Sciendo, 2019)Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug hydrolysis and degradation in acidic media, drug fluctuations, ... -
Characterization of human serum albumin's interactions with safranal and crocin using multi-spectroscopic and molecular docking techniques
(Elsevier B.V., 2019)Interaction mechanisms of human serum albumin (HSA) with safranal and crocin were studied using UV–Vis absorption, fluorescence quenching and circular dichroism (CD) spectroscopies as well as molecular docking techniques. ... -
Survey data for COVID-19 vaccine preference analysis in the United Arab Emirates
(Elsevier Inc., 2020)In response to the call for interdisciplinary research on the potential effects of the coronavirus pandemic [1], this article presents a novel data set on individuals’ COVID-19 vaccine preferences in the United Arab Emirates ... -
Scale validation for the identification of falsified hand sanitizer: public and regulatory authorities perspectives from United Arab Emirates
(BioMed Central Ltd, 2020)Background: Since the time of declaration of global pandemic of COVID-19 by World Health Organization (WHO), falsified hand sanitizers surfaced regularly in markets, posing possible harm to public due to unlisted inclusion ... -
First derivative ATR-FTIR spectroscopic method as a green tool for the quantitative determination of diclofenac sodium tablets
(F1000 Research, 2020)Background: Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a rapid quantitative method which has been applied for pharmaceutical analysis. This work describes the utility of first derivative ... -
Experiential community pharmacy training: Assessment of students’ perceptions in the united arab emirates
(International Pharmaceutical Federation, 2020)Introduction: Community pharmacy settings provide places for promoting the effective and safe use of medicines all over the world. This study explored pharmacy students’ perceptions of the barriers they had faced during ... -
The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons
(Elsevier Inc., 2020)Cuscuta reflexa has been traditionally used as an antiemetic. Additionally, it has been used in various herbal formulations for the treatment of emesis. So far, there is no scientific evidence of the plant extract as ... -
COVID-19 Vaccine Development in a Quadruple Helix Innovation System: Uncovering the Preferences of the Fourth Helix in the UAE
(MDPI AG., 2020)Successful development and uptake of vaccine technology in a Quadruple Helix Innovative health or economic system requires a clear understanding of society’s preferences as the fourth helix. With significant financial ...