Latest submissions
Now showing items 261-280 of 287
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Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy
(JMDGA., 2021)Background Bone dysplasias are a large group of disorders affecting the growth and structure of the skeletal system. Methods In the present study, we report the clinical and molecular delineation of a new form of syndromic ... -
Identification of the awareness level by the public of Arab countries toward COVID-19: Cross-sectional study following an outbreak
(BioMed Central, 2020)Background: The novel coronavirus disease 2019 (COVID-19) pandemic is a global challenge. Improving public awareness about preventive measures and disseminating appropriate information about COVID-19 has a critical role ... -
What are the beliefs and behaviours related to sport nutrition supplements, particularly regarding UAE regulatory issues, among male fitness centre members in Dubai?
(Elsevier B.V., 2020)Objectives: The current study sought to investigate how sport nutrition supplements are used among a population of gym users in Dubai, United Arab Emirates (UAE), and the factors that underlie the consumption patterns of ... -
Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity
(John Wiley and Sons Ltd., 2018)The presence of false positives in enzyme inhibition assays is a common problem in early drug discovery, especially for compounds that form colloid aggregates in solution. The molecular basis of these aggregates could not ... -
Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19
(Elsevier B.V., 2021)Coronaviruses are non-segmented and single stranded positive-sense RNA (+ssRNA) viruses. To date, 06 human coronaviruses (HCoVs) are reported; α-CoVs (HCoVs-NL63 and HCoVs-229E) and β-CoVs (HCoVs-OC43, HCoVs-HKU1, SARS-CoV, ... -
Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder
(Frontiers Media S.A., 2018)Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder characterized by two core behavioral symptoms, namely impairments in social communication and restricted/repetitive behavior. The molecular ... -
Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
(MDPI AG., 2020)The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the ... -
Evaluating quantity and quality of literature focusing on health economics and pharmacoeconomics in Gulf Cooperation Council countries
(Taylor and Francis Ltd., 2018)Background: The importance of pharmacoeconomics and health economics has been augmented. It has the potential to provide evidence to aid in optimal decision-making in the funding of cost-effective medicines and services ... -
Controlled release of pyrimidine compound using polymeric coated ZIF-8 metal-organic framework as glucagon-like peptide-1 receptor agonist carrier
(MDPI AG., 2020)This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment ... -
Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists in Lahore, Punjab, Pakistan
(Public Library of Science, 2018)Background and objectives Practice-based research (PBR) is of pivotal importance for hospital pharmacists which not only up-grades the profession but also improves the patient care. This study aimed to evaluate the attitude, ... -
A stochastic numerical analysis based on hybrid NAR-RBFs networks nonlinear SITR model for novel COVID-19 dynamics
(Elsevier Ireland Ltd., 2021)Background: Mathematical modeling of vector-borne diseases and forecasting of epidemics outbreak are global challenges and big point of concern worldwide. The outbreaks depend on different social and demographic factors ... -
The Compulsory Licensing for Exploiting Patented COVID-19 Pharmaceutical Treatment: Legal Approaches of Some Arab Countries.
(Mary Ann Liebert Inc., 2021)This article deals with exploitation of a pharmaceutical patent to treat the novel coronavirus. The laws of several Arab nations, which regulate industrial property rights in regard to the use of compulsory licensing for ... -
Suboptimal Health, Dietary Supplementation, and Public Health Approaches to Regulatory Challenges in Dubai
(SAGE., 2020)Objectives: Presently, limited data are available on dietary supplements (DSs) and their associated effects on health status although the consumption of DS continues to expand. This study is aimed to explore the possible ... -
Micro-RNAs in the regulation of immune response against SARS CoV-2 and other viral infections
(Elsevier B.V., 2021)Background: Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18–24 nucleotide length RNA molecules. Recently, miRNAs have ... -
Investigation of fractal-fractional order model of COVID-19 in Pakistan under Atangana-Baleanu Caputo (ABC) derivative
(Elsevier B.V., 2021)This manuscript addressing the dynamics of fractal-fractional type modified SEIR model under Atangana-Baleanu Caputo (ABC) derivative of fractional order y and fractal dimension p for the available data in Pakistan. The ... -
Effects of beta-carboline alkaloids of Peganum harmala on induced rat ileum contractions
(EManuscript Technologies, 2020)Peganum harmala L., Zygophyllaceae popularly known as Wild Syrian rue, a well-known plant in folk medicine for many pharmacological uses including antispasmodic activity. Chemical composition of the plant showed that the ... -
First derivative ATR-FTIR spectroscopic method as a green tool for the quantitative determination of diclofenac sodium tablets
(F1000 Research, 2020)Background: Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a rapid quantitative method which has been applied for pharmaceutical analysis. This work describes the utility of first derivative ... -
Development and In Vitro Evaluation of Controlled Release Viagra® Containing Poloxamer-188 Using Gastroplus™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
(MDPI AG., 2021)Sildenafil is the active substance in Viagra® tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this ... -
iOntoBioethics: A Framework for the Agile Development of Bioethics Ontologies in Pandemics, Applied to COVID-19
(Frontiers Media S.A., 2021)Background: Few ontological attempts have been reported for conceptualizing the bioethics domain. In addition to limited scope representativeness and lack of robust methodological approaches in driving research design and ... -
Non Pharmaceutical Interventions for Optimal Control of COVID-19
(Elsevier, 2020)Background and Objective: The outbreak of the current pandemic begun from the first individual of a 55-year old from Hubei province in China, the disease instigated by the new coronavirus spreading across the world. ...