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Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity
(John Wiley and Sons Ltd., 2018)
The presence of false positives in enzyme inhibition assays is a common problem in early drug discovery, especially for compounds that form colloid aggregates in solution. The molecular basis of these aggregates could not ...
Controlled release of pyrimidine compound using polymeric coated ZIF-8 metal-organic framework as glucagon-like peptide-1 receptor agonist carrier
(MDPI AG., 2020)
This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment ...
Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases
(MDPI AG., 2020)
The endoplasmic reticulum (ER) is an important organelle involved in protein quality
control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress,
followed by an adaptive response via the ...
Anti-inflammatory, antibacterial, toxicological profile, and in silico studies of dimeric naphthoquinones from diospyros lotus
(International Academic Press, 2020)
Many researchers have studied socioeconomic, health, and security variables in developed countries; however, very few studies used multivariate analysis in developing countries. The current study contributes to the scarce ...
Non Pharmaceutical Interventions for Optimal Control of COVID-19
(Elsevier, 2020)
Background and Objective: The outbreak of the current pandemic begun from the first individual of a 55-year old from Hubei province in China, the disease instigated by the new coronavirus spreading across the world. ...
iOntoBioethics: A Framework for the Agile Development of Bioethics Ontologies in Pandemics, Applied to COVID-19
(Frontiers Media S.A., 2021)
Background: Few ontological attempts have been reported for conceptualizing the bioethics domain. In addition to limited scope representativeness and lack of robust methodological approaches in driving research design and ...
COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies
(MDPI, 2020)
Coronavirus disease 2019 (COVID-19), which reported in an outbreak in 2019 in Wuhan, Hubei province, China, is caused by the SARS-CoV-2 virus. The virus belongs to the beta-coronavirus class, along with the Middle East ...
Attitude, perception, willingness, motivation and barriers to practice-based research: A cross-sectional survey of hospital pharmacists in Lahore, Punjab, Pakistan
(Public Library of Science, 2018)
Background and objectives Practice-based research (PBR) is of pivotal importance for hospital pharmacists which not only up-grades the profession but also improves the patient care. This study aimed to evaluate the attitude, ...
Investigating prescribing errors in the emergency department of a large governmental hospital in Jordan
(Blackwell Publishing Ltd., 2020)
Background: Although prescribing errors (PEs) are the most common type of medication errors and cause morbidity and mortality, they have been rarely studied. Objective: The study aimed to investigate PEs incidence, types, ...
Phytochemical profiling, antioxidant and antiproliferation potential of Euphorbia milii var.: Experimental analysis and in-silico validation
(Elsevier B.V., 2020)
This study was aimed to investigate the anticancer potential of Euphorbia milii (E. milii) using an exquisite combination of phytopharmacological and advanced computational techniques. The chloroform fraction (Em-C) of E. ...