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Synthesis, molecular docking and ADMET studies of bis-benzimidazole-based thiadiazole derivatives as potent inhibitors, in vitro α-amylase and α-glucosidase
(Elsevier B.V., 2023)
Different research synthetic methods have been developed recently for the synthesis of bis-benzimidazole analogs to investigate various biological significances. In this present study, an attempt was made to synthesize a ...
Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors
(MDPI, 2023)
The need for new antibiotics has become a major worldwide challenge as bacterial strains keep developing resistance to the existing drugs at an alarming rate. Enoyl-acyl carrier protein reductases (FabI) play a crucial ...
Effect of Excipients on the Quality of Drug Formulation and Immediate Release of Generic Metformin HCl Tablets
(MDPI, 2023)
Generic medications are bioequivalent to brand-name medications, but the quality and purity of generic medications are still debatable. The aim of this study was to compare the generic product of metformin (MET) to its ...
Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity
(Springer Nature, 2023)
Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional ...
Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant Pathogens
(MDPI, 2023)
The human body is a superorganism that harbors trillions of microbes, most of which inhabit the gut. To colonize our bodies, these microbes have evolved strategies to regulate the immune system and maintain intestinal ...
Patients’ views and experiences on the use and safety of directly acting oral anticoagulants: a qualitative study
(BioMed Central Ltd, 2023)
Background: Direct oral anticoagulants (DOACs) are considered high-risk medications and used to prevent thromboembolic events and stroke. This study aimed to examine patients’ views and experiences of DOACs use and factors ...
A Systematic Review of Human Trials on Mycoprotein - Way towards a Sustainable Ecosystem
(NLM (Medline), 2022)
Rapidly increasing global warming and world population calls for exploring untapped elements of biodiversity in a much broader sense. Though there exists much evidence on the importance of livestock and animal-derived ...
Development and Characterization of Nutritious Gluten-Free Doughnuts with Lupin and Inulin Flours
(MDPI, 2022)
Celiac disease is an immune-mediated disease caused by ingestion of gluten-containing products. The main aim of this study was to develop novel gluten-free doughnuts with high nutritional value using inulin and lupin flour. ...
COVID-19 Vaccines Status, Acceptance and Hesitancy among Maintenance Hemodialysis Patients: A Cross-Sectional Study and the Implications for Pakistan and Beyond
(MDPI, 2023)
COVID-19 vaccine hesitancy continues to be a widespread problem in Pakistan due to various conspiracy beliefs, myths and misconceptions. Since the hemodialysis population is at a higher risk of contracting infections, we ...
High throughput biochemical profiling, and functional potential analysis for valorization of grape peduncles
(Nature Research, 2023)
Vitis vinifera L., commonly known as grape is a major fruit crop in the world. Grapes seem to confer health benefits due to their chemical components, biological and antioxidant activities. The present study is conducted ...