Browsing Pharmacy by Author "AlNeyadi, Shaikha S."
Now showing items 1-2 of 2
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Controlled release of pyrimidine compound using polymeric coated ZIF-8 metal-organic framework as glucagon-like peptide-1 receptor agonist carrier
AlNeyadi, Shaikha S.; Amir, Naheed; Ghattas, Mohammad A.; Atatreh, Noor; Alketbi, Shaikha S.; Al Ajeil, Ruba; Adem, Abdu (MDPI AG., 2020)This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment ... -
The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation
Mahgoub, Radwa E.; Mohamed, Feda E.; Alzyoud, Lara; Ali, Bassam R.; Ferreira, Juliana; Rabeh, Wael M.; AlNeyadi, Shaikha S.; Atatreh, Noor; Ghattas, Mohammad A. (MDPI, 2022)The main protease enzyme (Mpro) of SARS-CoV-2 is one of the most promising targets for COVID-19 treatment. Accordingly, in this work, a structure-based virtual screening of 3.8 million ligand libraries was carried out. ...