Browsing Pharmacy by Author "Al-Sorkhy, M."
Now showing items 1-2 of 2
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Direct interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro
Al-Sorkhy, M.; Fifield, Bre Anne; Myers, Dorothy; Porter, Lisa Ann (Taylor and Francis Inc., 2016)Families of cyclin-like proteins have emerged that bind and activate cyclin dependent kinases (Cdk)s, directing the phosphorylation of noncanonical Cdk substrates. One of these proteins, Spy1, has demonstrated the unique ... -
Druggability analysis and classification of protein tyrosine phosphatase active sites
Ghattas, Mohammad A.; Raslan, Noor; Sadeq, Adel Shaban; Al-Sorkhy, M.; Atatreh, Noor (Dove Medical Press Ltd., 2016)Protein tyrosine phosphatases (PTP) play important roles in the pathogenesis of many diseases. The fact that no PTP inhibitors have reached the market so far has raised many questions about their druggability. In this ...