Browsing by Author "Ali, Bassam R."
Now showing items 1-2 of 2
-
Defect in phosphoinositide signalling through a homozygous variant in PLCB3 causes a new form of spondylometaphyseal dysplasia with corneal dystrophy
Ben-Salem, Salma; Robbins, Sarah M.; Sobreira, Nara Lygia Macena; Ali, Bassam R.; Al-Gazali, Lihadh I.; Lyon, A.; Al-Shamsi, A.M.; Islam, B.K.; Akawi, N.A.; John, A.; Thachillath, P.; Al Hamed, S.; Valle, D. (JMDGA., 2021)Background Bone dysplasias are a large group of disorders affecting the growth and structure of the skeletal system. Methods In the present study, we report the clinical and molecular delineation of a new form of syndromic ... -
The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation
Mahgoub, Radwa E.; Mohamed, Feda E.; Alzyoud, Lara; Ali, Bassam R.; Ferreira, Juliana; Rabeh, Wael M.; AlNeyadi, Shaikha S.; Atatreh, Noor; Ghattas, Mohammad A. (MDPI, 2022)The main protease enzyme (Mpro) of SARS-CoV-2 is one of the most promising targets for COVID-19 treatment. Accordingly, in this work, a structure-based virtual screening of 3.8 million ligand libraries was carried out. ...