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Direct interactions with both p27 and Cdk2 regulate Spy1-mediated proliferation in vivo and in vitro
(Taylor and Francis Inc., 2016)
Families of cyclin-like proteins have emerged that bind and activate cyclin dependent kinases (Cdk)s, directing the phosphorylation of noncanonical Cdk substrates. One of these proteins, Spy1, has demonstrated the unique ...
Druggability analysis and classification of protein tyrosine phosphatase active sites
(Dove Medical Press Ltd., 2016)
Protein tyrosine phosphatases (PTP) play important roles in the pathogenesis of many diseases. The fact that no PTP inhibitors have reached the market so far has raised many questions about their druggability. In this ...
Evaluation of certain pharmaceutical quality attributes of lisinopril split tablets
(MDPI AG., 2016)
Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical ...
A sedge plant as the source of Kangaroo Island propolis rich in prenylated p-coumarate ester and stilbenes
(Elsevier Ltd., 2016)
Propolis samples from Kangaroo Island, South Australia, were investigated for chemical constituents using high-field nuclear magnetic resonance spectral profiling. A type of propolis was found containing a high proportion ...